Volume 22, entitled Metal Ions in Bio-Imaging Techniques, of the series Metal Ions in Life Sciences deals with metal ions as tools in imaging. This dates back to the first half of the past century, when barium sulfate was orally given to patients undergoing X-ray examination. The use of contrast agents has since developed into a large interdisciplinary field encompassing not only medicine, but also chemistry, material sciences, physics, biology, engineering, and computer sciences. MILS-22 provides deep and current insights in 17 stimulating chapters on the new research frontiers of this fast growing field on bio-imaging ... and beyond. For example, adding bio-sensing yields theranostic agents, meaning diagnosis and therapy linked in the same molecule; ions of Gd, Mn, Fe, Co, Ir, 99mTc, etc., are involved. Other important topics are, e.g., metal complexes in paramagnetic Chemical Exchange Transfer (paraCEST), radiometals for Positron Emission Tomography (PET) imaging, or paramagnetic metal ion probes for 19F magnetic resonance imaging. MILS-22 is written by 57 internationally recognized experts from 12 countries, that is, from the US via Europe to China. The impact of this vibrant research area is manifested by more than 2300 references and nearly 120 figures, mostly in color, and several informative tables. To conclude, Metal Ions in Bio-Imaging Techniques is an essential resource for scientists working in the wide range from material sciences, enzymology, analytic, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that also excellent information for teaching is provided.

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

An investigation was conducted to examine the effect of a row of cylindrical surface dimples in reducing the heat load on a turbine blade leading edge model. The models consisted of a foam cylindrical leading edge with a flat afterbody fabricated from Plexiglass. A single coolant hole was located 21.5- from the leading edge, angled 20- to the surface and 90- from the streamwise direction. The leading edge diameter to hole diameter ratio was D/d = 18.7. A row of seven dimples was placed upstream of one of the coolant holes. Infrared thermography techniques were used to determine the adiabatic effectiveness, ? and heat transfer coefficient, h, distributions so that the net heat flux reduction could be calculated. Freestream conditions consisted of Reynolds numbers of 60,000 and 30,000 at both low turbulence and high turbulence.

Scientific Study from the year 2006 in the subject Business economics - Personnel and Organisation, grade: 2,0, Maastricht University (Faculty of Economics and Business Administration, Studiengang International Business), language: English, abstract: Inhaltsangabe: Abstract: Burnout is a multidimensional psychological syndrome that evolves as a reaction to chronic stress in the workplace. It results in an irrevocable depletion of a person's energies and emotional resources with various negative consequences for individuals and organizations. In the past 30 years researchers tried to understand the burnout construct in its complexity and offered diverse answers to questions of why burnout appears and how it can be measured. But despite the broad academic research on burnout, the knowledge base is still lacking a comprehensive approach on how to prevent burnout from happening and how to alleviate organizations from its the negative implications. This thesis gives insights by integrating various research findings with tangible management techniques. A theoretical model is constructed for offsetting burnout and its consequences. A list of 12 multidirectional propositions is given that managers may apply to proactively decrease burnout and its effects. The implementation of effective individual, managerial or organizational patterns to deal proactively with burnout depends largely on manager's clear and accurate understanding of the burnout construct, before acting on its consequences. For that reason it is inevitable for managers to comprehend the burnout phenomenon in its multidimensional and holistic whole. Accordingly, chapter two will explicate the theoretical burnout construct to a managerial audience. A summary of the historical and empirical research activities will be given in section 2.1 in order to provide a better understanding of how the knowledge base on burnout evolved over time to its current state. Section 2.2 offers explanations for the three burnout